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Although the exact molecular mechanisms behind this relationship remain to be elucidated, multiple studies have suggested that dietary TMAO promotes atherosclerosiswhich can lead to coronary artery disease if left uncheckedvia a combination of poor metabolic control (specifically, glucose intolerance and insulin resistance), overexpression of inflammatory markers 1 , and altered bile acid metabolism 10

In same study, treatment with potent inhibitor of PKR 2-aminopurine resulted in the reduction of apoptotic population by more than 50%

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Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism 36 , 539554, (2016)