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This cytokine secretion leads to the activation of CNS-resident immune cells (such as microglia, astrocytes, and macrophages), as well as to the production of cytokines, increased antigen-presenting cell (APC) function, and the enhanced production of reactive oxygen species (ROS) and reactive nitrogen species [196]

10.1128/mSphere.00585-19 55 LevineB.KroemerG

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