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However, sensitivity analyses, which involved excluding individual studies, revealed that omitting one outlier study [22], characterized by substantial variability compared to the others, resulted in a significant increase in WL for the GLP-1RAs group (SMD = 0.82

The requirement for proper documentation creates a compliance pressure point, and state boards have already shown a willingness to take enforcement action even when prescribers and compounding pharmacies believe they have met the standard within their clinical judgement

Effects on classic cardiovascular risk factors CVOTs on GLP-1RAs Data from the major CVOTs ELIXA, SUSTAIN-6, EXSCEL, HARMONY, PIONEER 6, LEADER, REWIND, and AMPLITUDE-O [53, 54, 56, 5963] support the overall safety of GLP-1RAs relative to major cardiovascular outcomes

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Given the high disease burden of NASH and limited therapeutic options currently available, the FDA has proposed an accelerated pathway for drug approval

Examining 168 pregnant women exposed to a GLP1-RA during the first trimester of pregnancy, alongside two reference groups (comprising pregnant women diagnosed with diabetes mellitus and overweight/obese pregnant women), we did not identify a specific pattern of birth defects