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Tirzepatide did not impact metabolic adaptation during weight loss in people with obesity

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Other medications can also affect shedding patterns
The researchers concluded this likely reflected metabolic adaptation rather than thyroid dysfunction (Biondi, 2010, Thyroid )

In a rat ischemia-reperfusion model using isolated perfused heart and whole animal, GLP-1 significantly decreased infarction size, and this protection was abolished by exendin 939 , as well as inhibitors of adenylyl cyclase, phosphatidylinositol 3-kinase (PI3K), and p42/44 mitogen-activated protein kinase (MAPK), suggesting that these pathways were involved in GLP-1mediated cardio-protection (Bose et al., 2005a)
