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Key changes every healthcare professional should know: Obesity is formally treated as a chronic, relapsing disease Lifestyle intervention remains essential, but anti-obesity medications are now considered a core component of care, not a last resort

Strengths Acts via multiple pathways (GLP-1, AMPK, microbiome) Has existing human data showing reductions in fasting glucose, HbA1c, lipids Support receptor expression and islet health Limitations Low absorption and bioavailability Gastrointestinal discomfort is common (diarrhea, cramping)

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