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GLP-1 receptor agonists like semaglutide and tirzepatide have transformed weight loss treatment, with clinical trials showing average weight loss of 15-22% of body weight

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This hypothesis remains under investigation, but it would explain why GLP-1 RAs sometimes improve testosterone more than expected based on the degree of weight loss achieved

Semaglutide mimics a hormone called glucagon-like peptide-1 (GLP-1) that binds to GLP-1 receptors

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Potential pancreatitis risk : As with other GLP-1-based therapies, there is a theoretical concern regarding pancreatitis, though causality has not been firmly established in trials to date