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It may also lead to exposition of hydrophobic clusters (that were otherwise buried to the core) making the protein aggregation prone species that ultimately form toxic oligomers

S., Piato A., Barcellos L

Nitric oxide (NO), inducible NO synthase (iNOS),prostaglandin E2 (PGE 2), cyclooxygenase-2 (COX-2), tumor necrosis factor- (TNF-), and other cytokines, such as interleukin-1 (IL-1) and interleukin-6 (IL-6), are shown as mediators

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Antioxidants (basel) 11(7):1240