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doi: 10.1073/pnas.84.5.1417 126 YorekMSCoppeyLJShevalyeHObrosovAKardonRHYorekMA
Gulati et al., 2006)
Wohlfart et al., 2008
Glutathiones role as a master antioxidant and crucial detoxification component makes it particularly valuable in formulations targeting cellular protection and immune support
There is a significant risk involved with assuming commercially available products developed using monolayers of cells will work efficiently with 3D cultures
In contrast, intracellular substrates, such as damaged mitochondria and protein aggregates, reach lysosomes mainly through autophagy, sequestered within autophagosomes that subsequently fuse with lysosomes to facilitate degradation
