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Emodin derivatives inhibit cancer cell proliferation, promotes apoptosis, and disrupts oncogenic signaling pathways in prostate, breast, lung, colon, melanoma, nasopharyngeal, pancreatic, and glioma cancers [495, 496]

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doi: 10.1016/S0016-5085(20)33220-0

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Moreover, Fer-1 treatment showed no or little effect on the apoptosis rate or necroptosis signaling in HSV-1-infected cells (Fig