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In addition to evaluating the risk of bias using the RoB 2 tool for RCTs and the ROBINS-I tool for non-randomized studies, we also assessed the overall quality of evidence using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) framework

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120Merlob P, Weber-Schndorfer C, Peters P, et al

Lung injury was graded from 0 (normal) to 4 (severe) based on neutrophil infiltration, congestion, edema, and alveolar wall thickness

Pharmaceuticals 16:1731