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What works in a controlled laboratory setting or in an animal model does not always translate to clinical success in humans

In that context, it is noteworthy that optimal function of stem cells depends on their highly specialized microenvironment, or niche [30, 31], and SASP factors deleteriously affect stem cells by altering this niche [32, 33]

Macrophage polarization: an important role in inflammatory diseases

A significant increase in IVD height was found in MSC/EPO group by 21 days of the experiment in comparison with that in MSC group

Silver nanoparticles (AgNPs) act through multiple mechanisms: releasing Ag ions that disrupt bacterial membranes, generating ROS, and binding thiol groups in enzymes to block essential metabolic processes [76]

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