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10.1016/j.cmet.2012.12.002 4 BajajL.LotfiP.PalR.RonzaA

Here, leveraging genome-wide CRISPRi screens in a damage-sensitized genetic background, we identified LC3/GABARAP-assisted stimulator for ESCRT recruitment (LASER), a multicomponent protein assembly that forms rapidly upon calcium release from damaged lysosomes and couples sensing of lysosomal membrane damage to ESCRT-dependent repair

For instance, in post mortem studies in the human brain from Alzheimers disease patients, it was demonstrated that the Se distribution pattern in the brain is seriously distorted (Rueli et al., 2015)

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15 Additional cell types involved in BBB transmigration As well as the interaction of tumour cells with brain ECs, additional cell types are also likely to be involved during migration across the BBB