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Despite the promising therapeutic potential of MT3 in HD, its clinical translation remains limited by technical and mechanistic challenges

The primary molecular pathways involved in senescence include: DNA Damage Response (DDR) and Senescence Induction: When DNA damage occurs, the DDR pathway is activated to repair the damage

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It was observed that there is very little change in the conformations of the ATD and TM domains

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Mass spectrometry analysis revealed a threefold increase in markers of neuronal membrane lipid peroxidation in Bmal1 knockout mice, reflecting heightened neuronal oxidative damage [179]