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This is because that chemotherapy can enhance cellular oxidative stress [293], rendering its synergies with pro-oxidative approaches naturally compatible
Therefore, the biogenesis of mitochondria requires exquisite coordination of both mitochondrial and nuclear genomes
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Additionally, environmental stressors like heavy metals and pesticides have been shown in experimental models to impair proteasome function, promote syn aggregation, and drive dopaminergic neuron loss, underscoring the multifaceted contribution of UPS impairment to PD pathogenesis [170]
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