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Depression's pathophysiology involves changes in several biological pathways, such as hypothalamicpituitaryadrenal axis hyperactivity, imbalances in the oxidant/antioxidant system, increased inflammatory cytokines, reduced BDNF levels, and diminished serotonergic neurotransmission in different brain areas [364]

It highlights recent evidence that alcohol induces a cascade of reactive oxygen species (ROS)-mediated lipid peroxidation and nicotinamide adenine dinucleotide (NAD + ) depletion, triggering mitochondrial dysfunction and metabolic imbalances in the liver, heart, pancreas, and brain

This review aims to provide a comprehensive synthesis of current knowledge on the ferroptosis-immune axis in COPD

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Razani B, Wang XB, Engelman JA, Battista M, Lagaud G, Zhang XL, Kneitz B, Hou H, Jr, Christ GJ, Edelmann W, Lisanti MP

In cases of diabetic nephropathy, chronic hyperglycemia induces the formation of autoantibodies against podocyte antigens, which cross-react with glomerular components, triggering complement activation and foot process effacement