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Elevated cytosolic NADH/NAD + and its resulting reductive stress were observed in early diabetic animals owing to increased oxidation of substrates ( e.g

Crane RK, Sols A (1953) The association of hexokinase with particulate fractions of brain and other tissue homogenates

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Kautzky-Willer, A., Harreiter, J

In recent years, increasing research efforts by pharmaceutical and biotechnology companies, academic institutions and publicprivate consortia have resulted in the evaluation of various technologies developed to deliver therapeutics to the CNS, some of which have entered clinical testing