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These proteins are paralogous homologs, sharing a similar amino acid sequence ( 2.2.1 In glucose metabolism Fetuin-A is one of the important proteins in insulin-dependent metabolism, which is associated with impaired insulin sensitivity, ultimately leading to IR and its complications ( 2.2.2 In lipid metabolism (1) Reduce adiponectin and impairs mitochondrial energy metabolism by inhibiting PPAR phosphorylation ( 2.2.3 Regulating inflammation Fetuin-A has shown pro-inflammatory effects in patients with IR, diabetes, obesity, atherosclerosis, MetS, NAFLD ( 2.3 Feuin-B Fetuin-B, like Fetuin-A, is mainly produced in the liver ( FETUB gene in rats significantly increased the level of fatty acid synthase, while the level of fatty acid metabolizing enzymes decreased, both lipid droplet formation and TG were significantly increased ( Selenoprotein PSelenoprotein P(SeP)is mainly produced by the liver

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