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Pregnancy and Breeding Caution: Safe use in pregnant or breeding animals has not yet been scientifically proven

Growth hormone stimulates hepatic IGF-1 production by binding to growth hormone receptors on liver cells, triggering intracellular signaling through the JAK2/STAT5 pathway that upregulates IGF-1 gene expression

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Given the importance of the cofactor in energy metabolism, NAD + is especially important in mitochondrial function, and in fact both NAD + and mitochondria are concentrated in energetically demanding tissues 1012

For multiple groups, the data were analyzed by one-way (ANOVA) followed by Tukeys and Dunnetts multiple comparison tests (details in figure legends)

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