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A refined definition of astrocyte reactivity includes four key features: (1) cellular, molecular and functional changes in response to CNS insults, (2) graded responses depending on insult severity, (3) context-dependent reactions influenced by intra- and intercellular signaling and (4) beneficial or detrimental effects on surrounding cells 35

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Monti D.A., Zabrecky G., Kremens D., Liang T.W., Wintering N.A., Bazzan A.J., Bowens B.K., Chervoneva I., Intenzo C., Newberg A.B

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