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J Cell Commun Signal (2023) 17(2):33352
In this structure, a conserved hydrophobic patch of the distal CTD interacts the N-terminal helix of G q , burying approximately 850 2 of accessible surface area (Figs
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The studies tested various doses including 0.25 mg, 0.5 mg, and 1 mg daily via subcutaneous administration over periods ranging from single doses to 24 weeks of continuous therapy
These parallel pro-death pathways collectively enable p53 to effectively induce ferroptosis, fulfilling its tumor-suppressive function
