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[ref] In animal models of insomnia, Lactobacillus reuteri improved sleep by upregulating GABA and other inhibitory neurotransmitters

This was achieved by up-regulating NF-E2-related factor-2 (NRF-2), kelch-like ECH-associated protein 1 (KEAP-1), and heme oxygenase 1 (HO-1), which are essential components of the antioxidant response pathway

HCY, as previously mentioned, can be converted into methionine by receiving a methyl group from 5-MTHF, or it can enter the transsulfuration pathway, where it is converted into cysteine

Meerarani P

The technical limitations of the study include that the number of labeled metabolites that can be visualized by MSI is smaller than that measurable by LCMS and that the signal for higher-order labeling (e.g., M4 in citrate and malate) is poor in MSI

166.0 166.1 Pedersen, Erik (August 17, 2019)
