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Thereafter, in HG-induced human retinal capillary endothelial cells (HRCEC), it was found that increased expression of Drp1, decreased expression of MFN2, increased mitochondrial reactive oxygen species (mtROS), and activation of NLRP3 inflammatory vesicles, and decreased protein expression of PINK1, Parkin, and VDAC1, whereas overexpression of VDAC1 could promote PINK1 expression and inhibit the activation of NLRP3, thus it was concluded that VDAC1 may be a potential target for the prevention and treatment of DR [161]
Fucoxanthin also reduces migration and invasion by inhibiting PI3K and p38, thus strengthening its candidature as a promising molecule in the war against brain tumors
"Advances in oral peptide therapeutics." Nature Reviews Drug Discovery
10.1002/oby.20674 27 ColmersI
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