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CDO1 can absorb cysteine competitively, thus restricting the process of GSH synthesis and promoting ferroptosis

however, the exact pathomechanisms are unclear

67 RaiA.TripathiP.DwivediS.DubeyS.ShriM.KumarS.et al (2011)

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Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, et al

4.2.1 NF1-associated OPG displays temporal and spatial specificity and is highly dependent on cell-of-origin and MAPK pathway activation The mTOR pathway had been well-implicated in NF1-associated disorders (85, 95, 96), and it was shown that MAPK pathway activation in NF1 -deficient astrocytes resulted from RAS hyperactivation (78, 85)