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Bioinformation (2014) 10:40612

Constipation Constipation may be from reduced food intake or change in diet as well as slower gut motility

Increased ER stress may be a self-protective signal transcription pathway after mild injury (Xie et al., 2016), In contrast, excessive ER stress triggers extensive neuronal death via CHOP activation

This unknown mechanism needs further investigation

130,131 Most studies indicate that IDH2 is also significantly upregulated in ESCC, 132 ovarian cancer, 133 lung cancer and other types of cancer, 134 playing a pro-oncogenic role

This creates more aggressive appetite suppression and metabolic effects than single or dual-receptor agonists