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In the TME, excessive H 2 O 2 can promote cancer cell proliferation, survival, and metastasis by persistently activating pro-oncogenic signaling pathways such as NF-B and HIF-1, inducing DNA damage that leads to genomic instability, and fostering an immunosuppressive milieu that aids tumor immune evasion [199]

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Sabharwal S, Nelson SC, Sontich JK