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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation

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STRING online database ( was used for analyzing the PPI of common genes and Cytoscape software ( was employed for visualizing the PPI network of common genes in Fig 4B

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In brief, a human vulvar epithelial cell line A-431 (Deutsche Sammlung von Mikroorganismen und Zellkulturen

And allowing the powder to dissolve passively without shaking or agitation