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This hormone stimulates melanogenesis, or the production of melanin pigment in melanocytes, which in turn makes skin appear darker. These effects are temporary, of course, as they fade when you discontinue usage of the product

Biguanides (Metformin) The biguanides are a class of drug that functions to lower serum glucose levels by enhancing insulin-mediated suppression of hepatic glucose production and enhancing insulin-stimulated glucose uptake by skeletal muscle

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Whitwell J.L., Crum W.R., Watt H.C., Fox N.C

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Data were expressed as mean standard deviation 76 and evaluated using Students t -test or Ordinary one-way ANOVA test for comparison with WT samples