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10.1155/2016/3928714 135 RenY.ShenH

Feb 2006;52(2):278-285

Rather than supplying glutathione directly, this complex supports the body's own production pathway with three carefully chosen ingredients: N-Acetyl-L-Cysteine (NAC), Alpha-Lipoic Acid (ALA) and Selenium, each widely recognised for its role in the glutathione pathway

The parasite genome demonstrates significant instability characterized by aneuploidy, copy number variations (CNVs), and single nucleotide polymorphisms that collectively facilitate rapid adaptation to therapeutic interventions ( Leishmania to develop resistance through various mechanisms including altered drug transport, target modification, and enhanced metabolic detoxification pathways ( Leishmania serves as an evolutionary advantage, allowing rapid selection of resistant populations under drug pressure

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10.1016/j.ejphar.2004.03.042