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In the case of the most commonly used rat model for experiments, it can be observed that more than 70% of the DARs associated with methamphetamine (METH) exposure that are conserved between rats and humans can only indicate that these regions have maintained somewhat similar gene regulatory functions during evolution

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We used this model for molecular replacement into the wild-type data set to build a complete 1.5 model (PDB 5W4A [ Ramachandran statistics were 98.1% favored, 1.90% allowed, and 0.00% outliners)