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While clinical development for obesity was discontinued in 2007 after a Phase IIb trial failed to achieve its primary endpoint, the peptide remains a valuable research tool for investigating adipose tissue biology, lipolytic pathways, and receptor-independent signaling mechanisms

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The mechanism appears to involve increased serotonin synthesis in substantia nigra, a regional pattern unlike any existing antidepressant drug

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Elevated homocysteine is a marker for cardiovascular risk and may also indicate B12 deficiency