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10.1001/archpsyc.62.4.444 90 NorthA.SwantJ.SalvatoreM

Not only do these roles originate from the receptors constitutive activity, but recent data indicate that GHSR1a dimerizes with a wide array of other receptors

[DOI] [PMC free article] [PubMed] [Google Scholar] Keck PE, Jr, Mintz J, McElroy SL, Freeman MP, Suppes T, Frye MA, Altshuler LL, Kupka R, Nolen WA, Leverich GS, Denicoff KD, Grunze H, Duan N, Post RM

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Zecchin A

With age, GSH levels decrease by up to 50% compared to young subjects, contributing to increased oxidative stress and chronic low-grade inflammation (inflammaging). In the anti-ageing field, GSH IV acts on three main levels: direct neutralisation of free radicals and protection of dermal collagen, modulation of inflammation through NF-B inhibition, and reduction of melanogenesis through tyrosinase inhibition with clinically observable effects on skin tone and luminosity. The most robust clinical evidence concerns neuroprotection (improvement of motor symptoms in Parkinson's disease) and protection from chemotherapy-induced neuropathy