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In ACE2 knockout mice, which are prone to colitis and experience altered microbiome ecology, nicotinamide administration restores the microbiome composition to control levels and ameliorates gastrointestinal symptoms of colitis [178]

According to a recent retrospective clinical study, patients with various statuses of HER2 (heterogenous, reduced, and loss) benefited from T-DXd, 424 while these patients showed limited response to T-DM1