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Zhao Y, Yang J, Shi J, Gong Y-N, Lu Q, Xu H, et al

and (b) a catalytically active closed conformation, where the Mg 2+ -isocitrate complex is able to bind between the large and small domains of the enzyme, consequent to relief of the steric impediment by Asp279 to the Mg 2+ -isocitrate complex binding

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PEGylated PFMSNs appeared to minimize the risk of cumulative intoxication to the brain