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In homeostatic equilibrium state, Nrf2 binds to Kelch-like epichlorohydrin-associated protein 1(Keap1) in cytoplasm to form a stable complex, and relies on ubiquitination and proteasomal degradation to maintain its low expression level

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It is made from two amino acidslysine and methionineand is stored mainly in muscles, the heart, and the brain

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3.2.2 Curcumin It is a polyphenol derived from the rhizome of Turmeric longa with numerous medicinal properties, capable of influencing the immune system (Gautam et al., 2007