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Finally, a recent study revealed that peroxisome proliferator-activated receptor alpha (PPAR) upregulated the expression of CPT1C, in a p-53 independent way, modulating proliferation and senescence of tumor cells 49
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PPARs The currently approved PPAR agonists include fenofibrate, pioglitazone hydrochloride, and rosiglitazone, which are primarily used to treat metabolic syndrome, CVD, and diabetes and have shown significant efficacy in clinical studies
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Dietary modifications can significantly impact symptom management
