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Food & Drug Administration

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Powers JH, et al: Sample size and ethics non-inferiority trials

Liraglutide is effective for weight loss and blood sugar control, but is less potent than newer GLP-1 medications such as semaglutide (Ozempic, Wegovy, and Rybelsus) and tirzepatide (Mounjaro and Zepbound), which provide greater weight loss and better sugar control

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This framework supports reliable physicochemical performance, including solubility behavior and stability in experimental conditions, enabling consistent results in signaling, metabolic, and biochemical assays