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[DOI] [PubMed] [Google Scholar] Paulsen G, Cumming KT, Holden G, Hallen J, Ronnestad BR, Sveen O, Skaug A, Paur I, Bastani NE, Ostgaard HN, Buer C, Midttun M, Freuchen F, Wiig H, Ulseth ET, Garthe I, Blomhoff R, Benestad HB & Raastad T (2014
Whether its genetic pigmentation, long screen hours, poor sleep, stress, or harsh sun exposure, under-eye darkness can make the face look tired, aged, and dull even when the skin is otherwise healthy
J Biol Chem , 279:4793947951
Studies have explored its potential in models of ulceration, inflammatory bowel disease analogues, and intestinal fistulas
The IGF-1R promoter exhibits a high basal transcriptional activity, and is under physiological control of nutritional factors (Olchovsky et al, 1993), hormonal stimulation (Clarke et al, 1997) and the developmental stage (Bondy et al, 1992)
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