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They also lost up to 16 pounds (about 7.6% of their body weight) on average while taking the highest dose, and hadn't plateaued by the end of the study, suggesting even more weight loss could be possible

Participants receiving tirzepatide alongside apitegromab retained significantly more lean mass than those receiving tirzepatide and placebo, while achieving broadly comparable overall reductions in body weight

The survey found that 57% were more interested in seeing GLP-1s approved for sleep apnea, followed by 56% for chronic heart failure, 47% for NASH, and 37% for chronic kidney disease

Journal of Clinical Endocrinology and Metabolism, 97 ,

As a result, clinicians have avoided using GLP-1 receptor agonists in patients with a history of acute pancreatitis

an indicator of lipid peroxidation) was observed