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Currently, there are four main treatments propelling this market forward: Ozempic and Wegovy (semaglutide: a GLP-1 agonist, developed by Novo Nordisk) Mounjaro and Zepbound (tirzepatide: a dual agonist targeting both GLP-1 and GIP (Gastric inhibitory polypeptide) receptors, developed by Eli Lilly) These medications are administered subcutaneously with the assistance of injection pens

In addition, TNF, IL-1 and PMA have been shown to upregulate SOD2 gene through a complex intronic enhancer sequence binding involving NFB, CCAAT-enhancer binding protein (C/EBP), Sp-1 and nuclear factor (NF)-1 (218, 247)

Dysfunction in the gut barrier (intestinal hyperpermeability or leaky gut) appears in most autoimmune conditions, potentially serving as both a trigger for initial autoimmune development and a perpetuating factor that maintains immune dysregulation