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Romina and Alba anthocyanin extracts reduce fibrosis in uterine fibroid cells and inhibit ECM components such as FN, COL1A1, and Activin A

Suppression of Signal Transducer and Activator of Transcription 3 Activation by Butein Inhibits Growth of Human Hepatocellular Carcinoma In Vivo
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Studies have found that under hypoxic conditions, HIF1 induced STAT3 via JAK or adenylate receptor 2B pathway, which upregulates the IL-6 and NANOG to maintain the CSC phenotype and also enhances the production of VEGF, required for the self-renewal ability of CSCs (79)
