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During the past several years we have created mathematical models for different parts of one-carbon metabolism [1621]

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Besides Gpx1, Gpx4 displays preference for lipid hydroperoxides ( Figure 3 ), and hence plays a key role in protecting phospholipids, cholesteryl esters and cardiolipin and defense against apoptosis and maintenance of ETC and OXPHOS (Cole-Ezea et al., 2012)

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