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Unlike treatment with GLP-1RAs, which generally leads to body weight and fat mass reduction, pioglitazone dose-dependently increases body weight and fat mass

In 2020, Trulicity also received FDA approval for the reduction of cardiovascular risk in adults with type 2 diabetes

In fact, Medicare is legally prohibited from covering drugs prescribed specifically for weight loss

The MHRA has issued Drug Safety Updates highlighting this risk with various transdermal products

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