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10.1016/j.spinee.2013.08.028 73 StrmerT.RaumE.BuchnerM.GebhardtK.SchiltenwolfM.RichterW.et al (2005)

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As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity