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Liraglutide activated multiple signaling cascades in PSCs, and the extracellular signal-regulated kinase pathway mediated the PSCs proliferation

4 Discussion The present meta-analysis, incorporating 93 randomized controlled trials with over 1.85 million participants, provides the most comprehensive synthesis to date of the relationship between GLP-1 receptor agonists (GLP-1 RAs) and gastrointestinal (GI) cancer risk
Researchers also examined major adverse CV events in patient subgroups on the basis of major adverse CV event rates in the placebo group, the presence or absence of CVD, HbA1c level, trial duration, treatment dosing interval, structural homology to human GLP-1 or exendin-4, BMI, age and eGFR
