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146,147 UC patients have been shown to have significantly diminished gut microbiota diversity, with an increase in the abundance of harmful bacteria and a decrease in the abundance of beneficial bacteria, which affects the immune regulation and inflammatory response of the gut, thereby exacerbating symptoms and promoting the progression of the disease

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10.1074/jbc.M507977200 123 LucasJ

GI changes (constipation or diarrhea) are more often linked to B12 deficiency or underlying gut conditions that also impair B12 absorption

Capacity limits of asialoglycoprotein receptor-mediated liver targeting

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